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Puma Biotechnology
Puma Biotechnology
(PBYI)
Puma Biotechnology is a publicly traded biopharmaceutical company (NASDAQ: PBYI) headquartered in Los Angeles, CA.
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Trade Name
Drug Name
Approved
Patent Expires
Indication
Nerlynx
Neratinib
2017-07-17
2025-2031
Breast neoplasms
Clinical Trials
Therapeutic Areas:
All
Classification:
All
Approval:
All
Status:
All
Phases:
All
Drug Name
Phase 1
Phase 2
Phase 3
Phase 4
Indication
Neratinib
healthy volunteers/patients
,
myelodysplastic syndromes
,
myeloid leukemia acute
,
hematologic neoplasms
,
pancreatic neoplasms
,
myeloproliferative disorders
,
non-hodgkin lymphoma
,
primary myelofibrosis
,
multiple myeloma
,
precursor cell lymphoblastic leukemia-lymphoma
,
b-cell chronic lymphocytic leukemia
,
bcr-abl positive chronic myelogenous leukemia
,
myelomonocytic leukemia chronic
,
anemia
,
hodgkin disease
,
leukemia myeloid chronic atypical bcr-abl negative
,
myelodysplastic-myeloproliferative diseases
,
plasma cell neoplasms
,
myeloid leukemia chronic-phase
,
myeloid leukemia
,
myeloid leukemia accelerated phase
,
myelomonocytic leukemia juvenile
,
preleukemia
,
blast crisis
,
thrombocytosis
,
syndrome
,
lymphoid leukemia
,
erbb-2 genes
,
erbb genes
,
ovarian epithelial carcinoma
,
liver failure
,
hepatic insufficiency
,
esophageal neoplasms
,
neoplasms
,
neoplasm metastasis
,
triple negative breast neoplasms
,
brain neoplasms
,
adenocarcinoma
,
carcinoma
,
non-small-cell lung carcinoma
,
stomach neoplasms
,
leukemia
,
prostatic neoplasms
,
castration-resistant prostatic neoplasms
,
lymphoma
,
diarrhea
,
colorectal neoplasms
,
lung neoplasms
,
ovarian neoplasms
,
inflammatory breast neoplasms
,
female genital neoplasms
,
neurofibromatosis 2
,
acoustic neuroma
,
meningioma
,
ependymoma
,
neurofibromatosis 1
,
neurofibromatoses
,
neurofibroma
,
neurilemmoma
,
hemangiosarcoma
,
glioblastoma
,
central nervous system neoplasms
,
nervous system neoplasms
,
endometrial neoplasms
,
fallopian tube neoplasms
,
lobular carcinoma
,
invasive hydatidiform mole
,
breast neoplasms
,
recurrence
,
biliary tract neoplasms
,
uterine cervical neoplasms
,
urinary bladder neoplasms
,
neoadjuvant therapy
Fam-trastuzumab deruxtecan-nxki
stomach neoplasms
,
esophageal neoplasms
Ado-trastuzumab emtansine
multiple myeloma
,
plasma cell neoplasms
Albumin
neoplasms
,
non-small-cell lung carcinoma
,
lung neoplasms
,
neoplasm metastasis
Aglatimagene besadenovec
leukemia
,
hematologic neoplasms
,
neoplasms
,
b-cell chronic lymphocytic leukemia
,
prolymphocytic leukemia t-cell
,
prolymphocytic leukemia
,
prostatic neoplasms
Alisertib
head and neck neoplasms
,
gastrointestinal neoplasms
,
digestive system neoplasms
,
pancreatic neoplasms
,
b-cell chronic lymphocytic leukemia
,
colorectal neoplasms
,
mucinous adenocarcinoma
,
colonic neoplasms
,
rectal neoplasms
,
cystadenocarcinoma
,
urogenital neoplasms
,
central nervous system neoplasms
,
thoracic neoplasms
,
mycoses
,
sezary syndrome
,
mycosis fungoides
,
hairy cell leukemia
,
intraocular lymphoma
,
precursor t-cell lymphoblastic leukemia-lymphoma
,
plasmablastic lymphoma
,
large granular lymphocytic leukemia
,
large-cell lymphoma immunoblastic
,
lymphomatoid granulomatosis
,
lymphoid leukemia
,
hematologic neoplasms
,
enteropathy-associated t-cell lymphoma
,
female genital neoplasms
,
lip neoplasms
,
male genital neoplasms
,
papilloma
,
triple negative breast neoplasms
,
brain neoplasms
,
glioblastoma
,
glioma
,
gliosarcoma
,
ependymoma
,
astrocytoma
,
oligodendroglioma
,
pancreatic ductal carcinoma
,
acinar cell carcinoma
,
neoplasms
,
recurrence
,
breast neoplasms
,
mantle-cell lymphoma
,
b-cell lymphoma
,
adenocarcinoma
,
lung neoplasms
,
non-hodgkin lymphoma
,
follicular lymphoma
,
large b-cell lymphoma diffuse
,
burkitt lymphoma
,
leukemia
,
prostatic neoplasms
,
carcinoma
,
small cell lung carcinoma
,
myeloid leukemia acute
,
non-small-cell lung carcinoma
,
neuroblastoma
,
ovarian neoplasms
,
hodgkin disease
,
b-cell lymphoma marginal zone
,
waldenstrom macroglobulinemia
,
large-cell lymphoma anaplastic
,
immunoblastic lymphadenopathy
,
myeloid leukemia
,
multiple myeloma
,
melanoma
,
squamous cell carcinoma of head and neck
,
precursor cell lymphoblastic leukemia-lymphoma
,
adult t-cell leukemia-lymphoma
,
t-cell lymphoma cutaneous
,
t-cell leukemia
,
sarcoma
,
leiomyosarcoma
,
plasma cell neoplasms
,
invasive hydatidiform mole
,
postmenopause
,
teratoma
,
rhabdoid tumor
,
phenylketonurias
,
squamous cell carcinoma
,
urinary bladder neoplasms
,
transitional cell carcinoma
,
fallopian tube neoplasms
,
peritoneal neoplasms
,
malignant mesothelioma
,
mesothelioma
,
myelodysplastic syndromes
,
preleukemia
,
syndrome
,
fibrosarcoma
,
liposarcoma
,
neurofibrosarcoma
,
malignant fibrous histiocytoma
,
nerve sheath neoplasms
,
extranodal nk-t-cell lymphoma
,
osteosarcoma
,
kidney neoplasms
,
ewing sarcoma
,
rhabdomyosarcoma
,
primitive neuroectodermal tumors
,
primitive neuroectodermal tumors peripheral
,
hepatoblastoma
,
embryonal rhabdomyosarcoma
,
neuroectodermal tumors
,
lymphoma
,
t-cell lymphoma
,
t-cell lymphoma peripheral
,
primary myelofibrosis
,
megakaryoblastic leukemia acute
Edrecolomab
hereditary angioedemas
,
angioedema
Aspartame
prostatic hyperplasia
,
hyperplasia
,
healthy volunteers/patients
,
respiratory tract diseases
,
respiration disorders
,
hyperhidrosis
,
kidney diseases
,
obesity
,
weight loss
,
burns
,
bronchiectasis
,
respiratory tract infections
,
skin diseases
,
premature obstetric labor
,
heart failure
,
pulmonary edema
,
amyloidosis
,
bacterial infections
,
liver diseases
,
hepatic insufficiency
,
sepsis
,
neoplasms
,
multiple myeloma
,
plasma cell neoplasms
,
common cold
,
breast neoplasms
,
rhinitis
,
tuberculosis
,
atherosclerosis
,
obstructive lung diseases
,
virus diseases
,
pancreatic neoplasms
,
lymphoma
,
follicular lymphoma
,
allergic rhinitis
,
pulmonary tuberculosis
,
coronary disease
,
coronary artery disease
,
myocardial ischemia
,
heart diseases
,
carcinoma
,
hepatocellular carcinoma
,
liver neoplasms
,
precursor cell lymphoblastic leukemia-lymphoma
,
precursor t-cell lymphoblastic leukemia-lymphoma
,
sjogren's syndrome
,
xerostomia
,
ulcer
,
buruli ulcer
,
hiv infections
,
malaria
,
systemic lupus erythematosus
,
infections
,
acquired immunodeficiency syndrome
,
vivax malaria
,
type 2 diabetes mellitus
,
human influenza
,
communicable diseases
,
hemolysis
,
neoplasm metastasis
,
bone fractures
,
parkinson disease
,
pemphigus
,
migraine disorders
,
depression
,
major depressive disorder
,
depressive disorder
,
churg-strauss syndrome
,
granulomatosis with polyangiitis
,
systemic vasculitis
,
eosinophilic granuloma
,
neisseria meningitidis
,
haemophilus influenzae type b
,
restless legs syndrome
,
psychomotor agitation
,
syndrome
,
covid-19
,
arthralgia
,
recurrence
,
ovarian neoplasms
,
anthrax
,
asthma
,
chronic obstructive pulmonary disease
,
lung diseases
,
diabetes mellitus
,
hepatitis
,
hepatitis a
,
nausea
,
pulmonary eosinophilia
,
prostatic neoplasms
,
growth and development
,
neuralgia
,
herpes zoster
,
postherpetic neuralgia
,
herpes simplex
Bevifimod
renal cell carcinoma
,
human influenza
,
nutritional status
,
pneumococcal infections
,
pneumococcal pneumonia
,
leishmaniasis
,
psoriasis
,
systemic lupus erythematosus
,
cutaneous lupus erythematosus
,
inflammatory bowel diseases
,
virus diseases
,
urticaria
,
tendon injuries
,
dermatitis
,
haemophilus influenzae
,
streptococcus pneumoniae
,
cancer pain
,
oncogenes
,
crohn disease
,
energy metabolism
,
endometrial neoplasms
,
carcinosarcoma
,
mullerian mixed tumor
,
fibrosis
,
idiopathic pulmonary fibrosis
,
pulmonary fibrosis
,
lung neoplasms
,
non-small-cell lung carcinoma
,
malaria
,
neoplasm metastasis
,
carcinoma
,
falciparum malaria
,
ovarian neoplasms
,
brain neoplasms
,
healthy volunteers/patients
,
prostatic neoplasms
,
asthma
,
recurrence
,
colorectal neoplasms
,
squamous cell carcinoma
,
multiple myeloma
,
plasma cell neoplasms
,
ovarian epithelial carcinoma
,
cutaneous malignant melanoma
,
skin neoplasms
,
type 1 diabetes mellitus
,
triple negative breast neoplasms
,
squamous cell carcinoma of head and neck
,
sickle cell anemia
,
myeloid leukemia acute
,
myeloid leukemia
,
leukemia
,
hepatitis b
,
chronic hepatitis b
,
hepatitis
,
primary myelofibrosis
,
hepatocellular carcinoma
,
liver neoplasms
,
fallopian tube neoplasms
,
pancreatic neoplasms
,
neuralgia
,
hematologic neoplasms
,
ductal carcinoma
,
circulating neoplastic cells
,
uterine neoplasms
,
uterine cervical neoplasms
,
glioma
,
streptococcus agalactiae
,
lymphoma
,
follicular lymphoma
,
neisseria meningitidis
,
haemophilus influenzae type b
,
invasive hydatidiform mole
,
biliary tract neoplasms
,
uveal neoplasms
,
respiratory tract diseases
,
respiration disorders
,
proteinuria
,
focal segmental glomerulosclerosis
,
cytomegalovirus infections
,
chronic hepatitis
,
kidney diseases
,
membranous glomerulonephritis
,
nephrotic syndrome
,
nephrosis
,
glioblastoma
,
endometrioid carcinoma
,
breast diseases
,
squamous cell neoplasms
,
neurofibromatosis 2
,
acoustic neuroma
,
neurofibromatosis 1
,
neurofibromatoses
,
neurofibroma
,
neurilemmoma
,
drug therapy
,
tuberculosis
,
pulmonary tuberculosis
,
adenocarcinoma of lung
,
disease progression
,
peritoneal neoplasms
,
inflammation
,
beta-thalassemia
,
thalassemia
,
sickle cell trait
,
essential thrombocythemia
,
polycythemia vera
,
thrombocytosis
,
polycythemia
,
ulcer
,
buruli ulcer
,
breast neoplasms
,
melanoma
,
rheumatoid arthritis
,
arthritis
,
head and neck neoplasms
,
inflammatory breast neoplasms
,
adenocarcinoma
,
respiratory syncytial virus infections
,
covid-19
,
bacterial infections
,
cellulitis
,
streptococcal infections
,
hepatitis a
,
stomach neoplasms
,
gastrointestinal neoplasms
,
digestive system neoplasms
,
infectious skin diseases
,
bacterial skin diseases
,
ductal carcinoma breast
,
renal insufficiency
,
mumps
,
measles
,
rubella
,
urinary bladder neoplasms
,
acute coronary syndrome
,
syndrome
,
rotavirus infections
,
otitis media
,
mucinous adenocarcinoma
,
meningitis
,
meningococcal meningitis
,
impetigo
,
respiratory syncytial viruses
,
herpes zoster
,
neoplasms
,
type 2 diabetes mellitus
,
diabetes mellitus
,
hiv infections
,
infections
,
acquired immunodeficiency syndrome
,
acne vulgaris
,
chronic obstructive pulmonary disease
,
communicable diseases
,
lung diseases
,
obstructive lung diseases
,
pneumonia
,
dental focal infection
,
focal infection
,
nausea
,
hiv
,
immunologic deficiency syndromes
,
ventilator-associated pneumonia
,
growth and development
,
immunologic tests
,
cognition
,
alzheimer disease
,
wasting syndrome
,
cachexia
,
dyslipidemias
,
insulin resistance
,
abdominal obesity
,
lipid metabolism
,
latent autoimmune diabetes in adults
,
community-acquired infections
,
abscess
,
folliculitis
,
staphylococcal infections
,
resistance training
,
exercise
,
depression
,
major depressive disorder
,
depressive disorder
,
thyroid neoplasms
,
papillary thyroid cancer
,
thyroid diseases
,
clostridioides difficile
Nepidermin
breast neoplasms
,
non-small-cell lung carcinoma
,
urinary bladder neoplasms
Retinol
renal cell carcinoma
,
carcinoma
,
recurrence
,
colonic neoplasms
,
rectal neoplasms
,
gastrointestinal neoplasms
,
digestive system neoplasms
,
gastrointestinal stromal tumors
,
colorectal neoplasms
,
pancreatic neoplasms
,
adenocarcinoma
,
myeloid leukemia chronic-phase
,
hematologic diseases
,
stomach neoplasms
,
brain stem neoplasms
,
philadelphia chromosome
,
nasopharyngeal carcinoma
,
nasopharyngeal neoplasms
,
psoriatic arthritis
,
arthritis
,
osteoporosis
,
bcr-abl positive chronic myelogenous leukemia
,
neoplasms
,
leukemia
,
myeloid leukemia
,
breast neoplasms
,
prostatic neoplasms
,
multiple sclerosis
,
sclerosis
,
bone diseases
,
osteitis deformans
,
hypertension
,
hypocalcemia
,
non-small-cell lung carcinoma
,
lung neoplasms
,
bone neoplasms
,
neoplasm metastasis
,
bone marrow diseases
,
vitamin d deficiency
,
angina pectoris
,
microvascular angina
,
beta-thalassemia
,
thalassemia
Hyoscyamine
healthy volunteers/patients
,
prediabetic state
,
glucose intolerance
,
hypoglycemia
,
sialorrhea
,
orthostatic intolerance
,
death
,
digestive system physiological phenomena
,
gastrointestinal motility
,
leukemia
,
acute disease
,
near-infrared spectroscopy
,
gastric bypass
,
gastrectomy
,
insulin resistance
,
vasodilation
,
vasoconstriction
,
allergic rhinitis
,
autonomic nervous system diseases
,
orthostatic hypotension
,
nervous system diseases
,
primary dysautonomias
,
cerebral palsy
,
hemorrhage
,
spinal fractures
,
pharmacokinetics
,
breast neoplasms
,
neoplasms
,
lung neoplasms
,
non-small-cell lung carcinoma
,
brain neoplasms
,
colonic neoplasms
,
rhinitis
,
allergic rhinitis seasonal
,
heart arrest
,
sarcoma
,
alveolar soft part sarcoma
,
blood coagulation disorders
,
hemostatic disorders
,
adenocarcinoma
,
diarrhea
,
granulosa cell tumor
,
amyotrophic lateral sclerosis
,
motor neuron disease
,
sclerosis
,
respiration
,
chronic obstructive pulmonary disease
,
obstructive lung diseases
,
regional blood flow
,
ocular physiological phenomena
,
ventilator-associated pneumonia
,
pneumonia
,
neutropenia
,
carcinoma
,
pancreatic neoplasms
,
ductal carcinoma
,
eye diseases
,
eye axial length
,
degenerative myopia
,
general anesthesia
,
emergence delirium
,
delirium
,
lymphoma
,
uveitis
,
premedication
,
replacement arthroplasty hip
,
chest pain
,
anisometropia
,
hypospadias
,
anterior uveitis
,
iridocyclitis
,
blood pressure
,
anesthesia and analgesia
,
heart rate
,
stomach neoplasms
,
neoplasm metastasis
,
retinal diseases
,
retinopathy of prematurity
,
cerebral infarction
,
replacement arthroplasty knee
,
hip fractures
,
blood coagulation
,
strabismus
,
colorectal neoplasms
,
myopia
,
neuromuscular blockade
,
anesthesia
,
hypotension
,
poisoning
,
postoperative pain
,
vomiting
,
nausea
,
postoperative nausea and vomiting
,
bradycardia
,
amblyopia
,
delayed emergence from anesthesia
,
drug-related side effects and adverse reactions
,
cesarean section
,
respiratory distress syndrome
,
newborn respiratory distress syndrome
,
organophosphate poisoning
,
spinal anesthesia
,
muscle hypotonia
,
intratracheal intubation
,
syndrome
,
cognitive dysfunction
,
headache
,
post-dural puncture headache
,
cardiac arrhythmias
,
disease progression
,
pregnancy
,
acute pain
,
cataract
,
retinal detachment
,
premature birth
,
laparoscopy
,
disease
,
fibrosis
,
muscle relaxation
,
obstructive sleep apnea
,
sleep apnea syndromes
,
apnea
,
respiratory insufficiency
,
pain
,
hypoxia
,
intubation
,
wounds and injuries
,
hip osteoarthritis
,
refractive errors
,
osteoarthritis
,
pulmonary atelectasis
,
gallstones
,
cholelithiasis
,
cholecystolithiasis
,
alzheimer disease
,
cognition disorders
,
neurocognitive disorders
,
postoperative period
,
anesthesia recovery period
,
liver diseases
,
liver cirrhosis
,
shoulder pain
,
newborn infant diseases
,
dental care for disabled
,
mydriasis
,
nephrolithiasis
,
kidney calculi
,
lower urinary tract symptoms
,
esophageal achalasia
,
conscious sedation
,
hepatocellular carcinoma
,
liver neoplasms
,
muscle weakness
,
myocardial infarction
,
infarction
,
heart block
,
inferior wall myocardial infarction
,
pleural effusion
,
lung diseases
,
mesothelioma
,
malignant pleural effusion
,
lymphadenopathy
,
pleural empyema
,
empyema
,
pneumothorax
,
pericardial effusion
,
pleural diseases
,
pleural neoplasms
,
hemothorax
,
procedural pain
,
cystic fibrosis
,
coronary artery disease
,
analgesia
,
glaucoma
,
conduction anesthesia
,
renal insufficiency
,
psychomotor agitation
,
hernia
,
depressive disorder
,
intravenous anesthesia
,
vascular diseases
,
heart diseases
,
obstetric labor complications
,
pregnancy rate
,
coronary disease
,
myocardial ischemia
,
angina pectoris
,
tachycardia
,
vasovagal syncope
,
syncope
,
hysterectomy
,
diabetic retinopathy
,
conjunctivitis
,
retinal neovascularization
,
pathologic neovascularization
,
carotid stenosis
,
aortic dissection
,
thoracic surgical procedures
,
cardiac catheterization
,
blood coagulation tests
,
postoperative cognitive complications
,
morbid obesity
,
diaphragmatic hernias congenital
,
diaphragmatic hernia
,
urinary bladder neoplasms
,
cardiovascular diseases
,
sudden death cardiac
,
sudden death
,
radiotherapy
,
respiratory aspiration
,
inhalation anesthesia
,
obesity
,
myalgia
,
irritable bowel syndrome
,
gastrointestinal diseases
,
dyspepsia
,
abdominal pain
,
digestive system diseases
,
pancreatitis
,
stress echocardiography
,
diastolic heart failure
,
psychology biofeedback
,
hypertension
,
drug overdose
,
suicide
,
prosthesis failure
,
confusion
,
aging
,
ventricular tachycardia
,
postural orthostatic tachycardia syndrome
,
fissure in ano
,
hemorrhoids
,
noise
,
constipation
,
gastric outlet obstruction
,
oculocardiac reflex
,
motor activity
,
exotropia
,
microvascular angina
,
variant angina pectoris
,
thoracic diseases
,
local anesthesia
,
postoperative complications
,
inguinal hernia
,
rhinoplasty
,
esthetics
,
systolic murmurs
,
atrioventricular block
,
depression
,
major depressive disorder
,
sick sinus syndrome
,
supraventricular tachycardia
,
brain hypoxia
,
pregnancy complications
,
myasthenia gravis
,
aortic aneurysm
,
ophthalmologic surgical procedures
,
bariatric surgery
,
acute kidney injury
,
projection
Caelyx
breast neoplasms
,
neoplasms
,
triple negative breast neoplasms
Endocrine
pancreatic neoplasms
,
prostatic neoplasms
,
hot flashes
Doxorubin
plasmacytoma
,
neuroblastoma
,
bone neoplasms
,
kidney neoplasms
,
adenoviridae infections
,
sarcoma
,
hodgkin disease
,
carcinoma
,
neoplasms
,
multiple myeloma
,
plasma cell neoplasms
,
invasive hydatidiform mole
,
hypersensitivity
,
hepatocellular carcinoma
,
adenocarcinoma
,
leiomyosarcoma
,
carcinosarcoma
,
mullerian mixed tumor
,
mesenchymoma
,
urinary bladder neoplasms
,
serous cystadenocarcinoma
,
peritoneal neoplasms
,
heart diseases
,
t-cell lymphoma
,
osteosarcoma
,
ewing sarcoma
,
primitive neuroectodermal tumors
,
primitive neuroectodermal tumors peripheral
,
neuroectodermal tumors
,
renal cell carcinoma
,
colorectal neoplasms
,
melanoma
,
lymphoma
,
triple negative breast neoplasms
,
fallopian tube neoplasms
,
non-hodgkin lymphoma
,
endometrial neoplasms
,
large b-cell lymphoma diffuse
,
b-cell lymphoma
,
hiv infections
,
recurrence
,
breast neoplasms
,
ovarian neoplasms
,
ovarian epithelial carcinoma
,
vomiting
,
nausea
,
hand-foot syndrome
,
drug-related side effects and adverse reactions
,
follicular lymphoma
,
paresthesia
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